Sometimes, the approach of linguists and commentators in interacting with the Quran has been as if the Quran is “the word of man.” In finding the meaning of the words and sentences of the Holy Quran, they compare it with the human applications of words and sentences. This approach can lead to ignoring the divine nature of the selection of materials, forms, and sentence structures in the Quran. The theory of the immutability of words considers the selection of materials, forms, and sentence structures in divine applications to be derived from the absolute knowledge and wisdom of God and to be infallible. In contrast, the selection of materials, forms, and sentence structures in human applications is always fallible. In this version of the presentation of the theory, priority and focus are given to the data of the human sciences. The hypothesis of the theory is as follows: the materials, forms, and sentence structures in the Quran are immutable. Therefore, finding the meaning of the words of the Quran by transforming them into other materials, forms, and sentence structures is an obstacle to achieving the correct and accurate divine meaning and intention. The method of formulating the theory is based on its basic deductive and demonstrative basis and in citing the verses of the Holy Quran, it is based on the study of the implications in the data of the Holy Quran, which is called ijtihad. The approach of the article is critical in quoting the competing meaning-findings. The innovation of the article is the formulation of a semantic theory and the establishment of a number of semantic rules for a correct and more accurate understanding of the Quran.